Key result
Prolonged linezolid linked to severe lactic acidosis and bilateral globi pallidi necrosis in mitochondrial J1 haplogroup.
Why the study?
The increasing use of linezolid has revealed various side effects including neurological complications linked to mitochondrial susceptibility that require further characterization.
Case Report (n=1)
No
Linezolid toxicity can present with a novel neurological complication of bilateral globi pallidi necrosis, particularly in patients with susceptible mitochondrial haplotypes.
May warrant vigilance for linezolid toxicity in J1 haplogroup carriers; leaves open mitochondrial genotyping for risk stratification.
The recent rise in the use of linezolid to treat a variety of resistant pathogens has uncovered many side effects. Some patients develop lactic acidosis, myelosuppression, optic or peripheral neuropathies, and myopathies. We evaluated an elderly patient who presented to the Emergency Room with linezolid toxicity and a novel neurologic complication characterized by bilateral globi pallidi necrosis. Mitochondrial ribosome inhibition was described to be the predisposing factor. The patient belongs to the mitochondrial J1 haplotype known to be associated with side effects of the drug. We recommend based on the molecular profile of the illness pretreatment considerations and complication management.
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Hassan et al. (2016) conducted a case report in Linezolid toxicity (n=1). Linezolid was evaluated on Development of bilateral globi pallidi necrosis and lactic acidosis. Prolonged linezolid therapy in a patient with the mitochondrial J1 haplogroup resulted in severe lactic acidosis and a novel neurological complication characterized by bilateral globi pallidi necrosis.
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