Key result
ANS dysregulation with reduced HRV is consistently linked to metabolic syndrome and elevated BP.
Why the study?
Autonomic imbalance is proposed to play an important role in the development of hypertension and adverse cardiovascular outcomes in individuals with metabolic syndrome, but the association requires systematic evaluation.
Does autonomic nervous system dysregulation associate with hypertension and increased cardiovascular risk in adults with metabolic syndrome?
Systematic Review
Does autonomic nervous system dysregulation associate with hypertension and increased cardiovascular risk in adults with metabolic syndrome?
Autonomic dysfunction is significantly associated with metabolic syndrome and contributes to hypertension and increased cardiovascular risk, suggesting its potential utility as an early biomarker for cardiometabolic risk stratification.
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May support autonomic assessment for cardiometabolic risk stratification; confirms associations and extends biomarker hypothesis for trials.
A 2025 study conducted a systematic review in Metabolic Syndrome. Autonomic nervous system dysregulation vs. Normal autonomic function was evaluated on Cardiovascular-related outcomes including hypertension and cardiovascular risk markers. Autonomic nervous system dysregulation, characterized by reduced heart rate variability and increased sympathetic activity, is consistently associated with metabolic syndrome and elevated blood pressure.
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