Key result
Nocturnal atrial overdrive pacing fails to reduce the apnea-hypopnea index in sleep-disordered breathing.
Why the study?
Atrial overdrive pacing was previously reported to markedly improve sleep-disordered breathing, but reproducibility and mechanisms were unclear.
Does nocturnal atrial overdrive pacing improve the apnea-hypopnea index in patients with sleep apnea and an implanted pacemaker or cardioverter defibrillator?
RCT (n=20)
Single-blind
randomized crossover
Does nocturnal atrial overdrive pacing improve the apnea-hypopnea index in patients with sleep apnea and an implanted pacemaker or cardioverter defibrillator?
Atrial overdrive pacing does not improve the apnea-hypopnea index and is inappropriate for treating sleep-disordered breathing in patients with implanted devices.
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Atrial overdrive pacing fails to improve sleep-disordered breathing; challenges prior positive reports and leaves open any adjunctive role.
Lüthje et al. (2005) conducted an RCT in Sleep Apnea (n=20). Atrial overdrive pacing vs. Nonpacing was evaluated on Apnea-hypopnea index. Nocturnal atrial overdrive pacing did not affect the apnea-hypopnea index, demonstrating it is inappropriate for treating sleep-disordered breathing.
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