Key result
Rabbit antibodies against purified Sm and RNP snRNPs demonstrate identical specificity to natural SLE antibodies.
Why the study?
The immunological specificity of antibodies elicited in rabbits against Sm and RNP antigens compared to naturally occurring SLE anti-Sm/RNP antibodies was investigated.
Rabbit anti-Sm/RNP immunization yields SLE-like autoantibodies; leaves open relevance to human autoimmunity and clinical translation.
Rabbits immunized with purified Sm and RNP small nuclear ribonucleoproteins (snRNPs) produced precipitating and hemagglutinating antibodies against these antigens. These antibodies had immunological specificity identical to the naturally occurring SLE anti-Sm/RNP antibodies as demonstrated by immunoprecipitation results and studies involving the characterization of immunoaffinity purified antigens isolated from the rabbit immune and SLE anti-Sm/RNP IgG affinity columns.
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Ishaq et al. (1984) studied Systemic Lupus Erythematosus. Immunization with purified Sm and RNP small nuclear ribonucleoproteins (snRNPs) vs. Naturally occurring SLE anti-Sm/RNP antibodies was evaluated on Immunological specificity of antibodies. Antibodies elicited in rabbits against purified Sm and RNP snRNPs demonstrated immunological specificity identical to naturally occurring SLE anti-Sm/RNP antibodies.
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