Key result
Female sex links to worse 3-month functional outcomes after ischemic stroke or TIA despite similar care.
Why the study?
Sex-related differences in acute stroke unit care and outcomes were not fully characterized in a large national registry.
Are there sex-related differences in acute stroke unit care and outcomes in patients with ischemic stroke or TIA?
Observational (n=47,209)
Yes
Are there sex-related differences in acute stroke unit care and outcomes in patients with ischemic stroke or TIA?
Female patients with acute ischemic stroke or TIA experience worse functional outcomes at 3 months and receive different secondary prevention medications compared to males.
No sex differences in acute stroke care quality after age adjustment; leaves open post-acute factors driving women's worse functional outcomes.
Evaluation of: Gattringer T, Ferrari J, Knoflach M et al. Sex-related differences of acute stroke unit care results from an Austrian stroke unit registry. Stroke 45, 1632-1638 (2014). The authors analyzed data from 47,209 patients diagnosed with ischemic stroke or transient ischemic attack from January 2005 to December 2012. In this study, epidemiological data, stroke type, diagnostics and clinical scores were analyzed for age-adjusted preclinical and clinical characteristics as well as quality of acute stroke care. Moreover, outcome at 3 months was included in a multivariate model corrected for demographic and clinical confounders. While there were no reported sex differences in stroke care and thrombolysis rates, males more often received magnetic resonance imaging (MRI) brain scans. From follow-up data, a worse functional outcome was observed for females in univariate and multivariate analysis. In fact, females were less likely to be prescribed statins and more likely to receive antiplatelet therapy. As a stroke risk factor, a higher rate of atrial fibrillation was observed in females.
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Arnao et al. (2014) conducted an observational in Ischemic stroke or transient ischemic attack (n=47,209). Female sex vs. Male sex was evaluated on Functional outcome at 3 months. Female patients with ischemic stroke or TIA had a worse functional outcome at 3 months compared to males, despite similar overall stroke care and thrombolysis rates.
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