Key result
Lower prognostic nutritional index is linked to ~8-fold higher in-hospital mortality in STEMI patients post-PCI.
Why the study?
The prognostic impact of poor nutritional status and cardiac cachexia in myocardial infarction is not clearly understood, and the prognostic value of PNI in STEMI patients needs evaluation.
Does the prognostic nutritional index predict mortality and major adverse cardiac events in patients with STEMI undergoing primary PCI?
Observational (n=1,823)
Does the prognostic nutritional index predict mortality and major adverse cardiac events in patients with STEMI undergoing primary PCI?
Relative Risk: 7.9 (95% CI 5–15.8)
The prognostic nutritional index is a strong, independent predictor of both in-hospital and 3-year mortality in patients with STEMI undergoing primary PCI.
Background: The prognostic impact of poor nutritional status and cardiac cachexia in myocardial infarction is not clearly understood. Recent studies have implied a prognostic value of the prognostic nutritional index (PNI) in colorectal surgeries and postoperative septic complications. The purpose of the current study is to evaluate the prognostic value of PNI in ST segment elevation myocardial infarction (STEMI) patients. Methods: We evaluated the in-hospital and long-term (3-year) prognostic impact of PNI on 1823 patients with STEMI undergoing primary percutaneous coronary intervention. Results: The patients with lower PNI had significantly higher in-hospital and long-term mortality and major adverse cardiac events. After adjustment for all confounders, the in-hospital mortality had higher rates at lower PNI level and that had 7.9-times higher mortality rates (95% CI: 5.0–15.8) than higher PNI level. The long-term mortality also had the higher rates at lower PNI level and that had 6.4-times higher mortality rates (95% CI: 4.4–12.4) than higher PNI level.
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Keskin et al. (2017) conducted an observational in ST segment elevation myocardial infarction (STEMI) (n=1,823). Lower prognostic nutritional index (PNI) vs. Higher PNI level was evaluated on In-hospital mortality (RR 7.9, 95% CI 5.0-15.8). Lower prognostic nutritional index in STEMI patients undergoing primary PCI was associated with 7.9-times higher in-hospital mortality (95% CI 5.0-15.8) and 6.4-times higher 3-year mortality.
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