Key result
Each one-point increase in NIHSS is linked to ~3% higher serum troponin in acute stroke.
Why the study?
Serum troponin is often elevated in patients with acute stroke, but the mechanism linking stroke severity and troponin levels is unknown.
Is stroke severity associated with serum troponin levels in patients with acute stroke?
Cohort (n=187)
No
Is stroke severity associated with serum troponin levels in patients with acute stroke?
There is a modest, independent association between stroke severity and serum troponin levels, suggesting a potential neurogenic basis for cardiac injury in acute stroke.
Answers are grounded in this paper and cite their sources.
Troponin elevation may reflect neurogenic injury but should not yet guide management; extends stroke-heart observations while leaving causality and actionability open.
Serum troponin is often elevated in patients with acute stroke and its mechanism is unknown. In a retrospective single-center cohort study, we evaluated the association between stroke severity and serum troponin in 187 patients with acute stroke using multivariable modified Poisson models. A one-point increase in the National Institutes of Health Stroke Scale (measure of stroke severity) was associated with a marginally higher serum troponin level in adjusted models (aIRR 1.03; 1.01–1.05, P = 0.001). The modest, yet potentially independent, association between stroke severity and serum troponins could suggest a neurogenic basis for a cardiac injury in patients with acute stroke.
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Kuczynski et al. (2023) conducted a cohort in Acute stroke (ischemic or intracerebral hemorrhage) (n=187). Stroke severity (NIHSS score) vs. Lower NIHSS score was evaluated on High-sensitivity serum troponin level (aIRR 1.03, 95% CI 1.01-1.05, p=0.001). A one-point increase in the National Institutes of Health Stroke Scale was associated with a 3% higher serum troponin level in patients with acute stroke (aIRR 1.03).
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