Key result
HFpEF case exhibits a phenotype of microvascular dysfunction, diffuse interstitial fibrosis, and elevated filling pressures.
Why the study?
A potential HFpEF phenotype associated with microvascular dysfunction, fibrosis, and elevated filling pressures requires further characterization.
Case Report (n=1)
This case illustrates a specific HFpEF phenotype characterized by the concurrent presence of microvascular dysfunction, interstitial fibrosis, and elevated filling pressures.
Hypothesis-generating for microvascular-fibrosis HFpEF phenotype; prospective studies needed to clarify therapeutic implications.
We report the case of a 55-year-old woman with heart failure with preserved ejection fraction (HFpEF), who presented with hypertensive urgency and pulmonary oedema. The patient was medically optimized and underwent cardiac catheterization revealing pulmonary hypertension, elevated pulmonary capillary wedge pressure, normal cardiac index, and non-obstructive coronary disease. Invasive evaluation of coronary flow revealed blunted coronary flow reserve and increased index of microvascular resistance. Cardiac magnetic resonance imaging demonstrated reduced global myocardial perfusion and diffuse interstitial fibrosis. This case exhibits a potential HFpEF phenotype associated with microvascular dysfunction, fibrosis, and elevated filling pressures.
No takes yet. Share an insight, caveat, or question.
Narang et al. (2017) conducted a case report in Heart failure with preserved ejection fraction (HFpEF) (n=1). A 55-year-old woman with HFpEF exhibited a phenotype associated with microvascular dysfunction, diffuse interstitial fibrosis, and elevated filling pressures.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: