Key result
Non-dipping blood pressure linked to ~38% higher augmentation index and more severe carotid atherosclerosis.
Why the study?
The relationship between arterial stiffness, augmentation index, carotid artery structure, and daily blood pressure profile in essential hypertension was not well characterized.
Is an abnormal circadian blood pressure profile associated with increased arterial stiffness and carotid atherosclerotic lesions in patients with essential hypertension?
Cross-Sectional (n=155)
Is an abnormal circadian blood pressure profile associated with increased arterial stiffness and carotid atherosclerotic lesions in patients with essential hypertension?
Absolute Event Rate: 21.6% vs 15.6%
p-value: p=<0.02
Patients with essential hypertension and an abnormal circadian blood pressure profile (non-dippers) exhibit increased arterial stiffness and more severe carotid atherosclerosis.
Observed associations in HTN; leaves open prognostic value and requires prospective validation before clinical use.
Objective. To study the relationship between arterial stiffness, augmentation index and the structure of the carotid arteries with daily blood pressure (BP) profile in patients with essential hypertension (HTN). Design and methods. Altogether 155 patients with HTN aged 30–70 years were examined. A physical examination, glucose, creatinin level and lipid profile (low- and high-density lipoproteins, and triglycerides) (biochemical analyzer Sinсhron SX‑4 DELTA, Beckman, USA), duplex scanning of carotid arteries (Sequoia‑512, Acuson, USA), and arterial stiffness assessment by pulse wave contour analysis (Angioscan‑01, Angioscan, Russia) were performed. Results . Augmentation index was associated with the nocturnal BP reduction in hypertensive males, but not females. In males, augmentation index was 6,8 ± 11,5 %, 12,7 ± 10,9 % and 14,5 ± 7,7 % for the dippers, nondippers and night-peakers, respectively (p < 0,05–0,01). In females, it was 19,9 ± 9,4 %, 20,7 ± 8,2 % and 17,1 ± 9,9 %, respectively (p > 0,05). The lowest values of augmentation index (15,6 ± 14,8 % versus 21,6 ± 13,4 % for non-dippers, p < 0,02) were found in patients with normal circadian BP profile. In addition, more severe carotid atherosclerotic lesions were found in non-dippers (23,2 ± 18,8 %) compared to dippers (13,7 ± 14,5 %, p < 0,01). Conclusions . Patients with HTN and abnormal circadian BP profile show higher augmentation index and more severe atherosclerotic lesions in carotid arteries.
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Полупанов et al. (2016) conducted a cross-sectional in essential hypertension (n=155). Abnormal circadian BP profile (non-dipping) vs. Normal circadian BP profile (dipping) was evaluated on Augmentation index (p=<0.02). An abnormal circadian blood pressure profile (non-dipping) in hypertensive patients was associated with a higher augmentation index (21.6% vs 15.6%, p<0.02) and more severe carotid atherosclerosis.