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Improvement in solubility of drug is a very formidable task in drug development.Approximately 40% of the new chemical entities currently being discovered are poorly water soluble drugs.The solubility and dissolution properties of drugs play a pivotal role in the process of formulation development.Among all newly discovered chemical entities most of the drugs are lipophilic and fail to reach market due to their poor water solubility.The ability to deliver poorly soluble drugs will grow in significance in the coming years.Similarly, generic drug manufacturers will need to exercise economically efficient methods of delivery as more low solubility drugs go off patent, in order to maintain a competitive edge and sufficiently compete as profit margins shrink in this price-sensitive industry.For this reason solubility enhancement is an important in future.
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Patil et al. (2016) studied this question.
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