Key result
Left atrial ejection fraction <36% linked to ~430% higher paroxysmal AF risk in chronic heart failure.
Why the study?
The risk of atrial fibrillation in patients with chronic heart failure and the effectiveness of different monitoring methods for early detection were not well established.
Does distant ECG monitoring and left atrial strain assessment improve the detection and risk prediction of atrial fibrillation paroxysms in patients with chronic heart failure?
Observational (n=100)
Does distant ECG monitoring and left atrial strain assessment improve the detection and risk prediction of atrial fibrillation paroxysms in patients with chronic heart failure?
Odds Ratio: 5.3 (95% CI 1.8–15.6)
p-value: p=0.001
Portable distant ECG monitoring and echocardiographic assessment of left atrial strain significantly enhance the detection and risk stratification of paroxysmal atrial fibrillation in heart failure patients.
Objective. To assess the risk of atrial fibrillation (AF) in patients with chronic heart failure (CHF) using a 24-hour Holter monitoring and distant ECG recording by portable single-channel device. Material and methods. The study involved 100 patients with CHF NYHA class I—IV with sinus rhythm. All patients underwent echocardiography with analysis of global strain of the left atrium and diastolic dysfunction. Along with a 24-hour Holter monitoring, additional three-day monitoring was performed. We also assessed distant ECG monitoring using telemedicine technologies (CardioQVARK device). The follow-up period was 1 month or until AF paroxysm. Results. Paroxysmal AF was detected in 20 (20%) patients. ECG in patients with complaints revealed 10% of AF paroxysms. Holter monitoring for 24, 48 and 72 hours revealed 5, 10 and 20% of AF paroxysms, respectively. When using the single-channel device CardioQVARK device 1, 2 and 3 times a day AF paroxysms were detected in 5, 55 and 15% of cases, respectively. This indicates a significant advantage of portable ECG recorder compared to other methods of sinus rhythm control in patients with CHF. There were significant changes of various indicators in patients with AF. Left atrial ejection fraction <36% was more common in patients with AF paroxysms (odds ratio (OR) 5.3, 95% CI 1.8—15.6, p=0.001). Global deformation of the left atrium <9.5% was more common in the same ones (OR 12.2, 95% CI 3.7—40.2, p=0.003). TDI E med <6.5 cm/s was more common in patients with AF (OR 10.2, 95% CI 2.2—47.6, p=0.001). Conclusion. Risk of AF in patients with CHF is high (up to 20%). Distant ECG monitoring methods are advisable in these ones for early detection of AF paroxysms and timely initiation of anticoagulant therapy. Echocardiography should be accompanied by assessment of global strain of the left atrium to determine the risk of AF.
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Zakharov et al. (2023) conducted an observational in Chronic heart failure (CHF) NYHA class I-IV with sinus rhythm (n=100). Distant ECG monitoring and Holter monitoring was evaluated on Paroxysmal AF associated with left atrial ejection fraction <36% (OR 5.3, 95% CI 1.8-15.6, p=0.001). Distant ECG and Holter monitoring detected paroxysmal AF in 20% of chronic heart failure patients, with left atrial ejection fraction <36% strongly predicting AF occurrence (OR 5.3; 95% CI 1.8-15.6; p=0.001).
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