Key result
Carbon dioxide and perfusion pressure changes alter cerebral blood flow via intact sinus nerves.
Why the study?
The effects of chemoreceptor and baroreceptor activity on cerebral circulation regulation were evaluated to understand their roles.
This preclinical study demonstrates that chemoreceptors and baroreceptors play a direct role in regulating cerebral blood flow.
Requires human validation before any clinical consideration; leaves open chemoreceptor contributions to cerebral autoregulation.
Ten experiments, each using two dogs, were performed to evaluate the effect of chemoreceptor and baroreceptor activity on the cerebral circulation. 2. The carotid bifurcation areas were vascularly isolated bilaterally and perfused with arterial blood from a second animal. 3. Bilateral vagotomy interrupted stimuli from the aortic group of receptors. 4. Administration of 5% carbon dioxide to the donor animal resulted in an increase in cerebral (cortical) blood flow in the recipient. 5. A change in the arterial perfusion pressure from the donor resulted in a reciprocal change in the cerebral blood flow of the recipient. These changes were abolished by sectioning the sinus nerves.
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James et al. (1975) studied Cerebral circulation regulation (n=20). Chemoreceptor and baroreceptor stimulation vs. Sinus nerve sectioning was evaluated on Cerebral (cortical) blood flow. Administration of 5% carbon dioxide or changes in arterial perfusion pressure altered cerebral blood flow, effects that were abolished by sectioning the sinus nerves.
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