Key result
Hospitalization for essential hypertension linked to reduced BP and a ~41% drop in resting norepinephrine.
Why the study?
The role of reduction in sympathetic reactivity in spontaneous blood pressure falls during hospitalization in patients with essential hypertension was unclear.
Does hospitalization reduce sympathetic reactivity in patients with essential hypertension?
Observational (n=12)
No
Does hospitalization reduce sympathetic reactivity in patients with essential hypertension?
Absolute Event Rate: 111% vs 188%
p-value: p=<0.05
Diminution of sympathetic activity may partly explain the late-stage spontaneous fall in blood pressure during hospitalization for essential hypertension.
May indicate reduced sympathetic activity during hospitalization in essential hypertension; leaves open its causal role in BP reduction and requires randomized confirmation.
We evaluated whether reduction in sympathetic reactivity plays a major role in the spontaneous falls in blood pressure (BP) experienced during hospitalization by patients with essential hypertension. In the present case BP fell on the 2nd day of hospitalization. The responses of plasma catecholamines (CA) and BP to both handgrip and tilting were not altered during either the first 24 hours or the entire 7 days of hospitalization. The effect of phentolamine on BP was similar on the 1st, 2nd and 7th days. However, the resting levels of plasma norepinephrine before handgrip, tilting and phentolamine were significantly diminished on the 7th day, but not on the 2nd day. In conclusion, the diminution of sympathetic activity may be partly responsible for the hospitalization-induced fall in BP in the late stages.
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Takata et al. (1990) conducted an observational in Essential hypertension (n=12). Hospitalization vs. Baseline (1st day of hospitalization) was evaluated on Resting plasma norepinephrine concentration (pg/ml) (p=<0.05). Hospitalization of patients with essential hypertension resulted in a spontaneous fall in blood pressure and a significant decrease in resting plasma norepinephrine from 188 pg/ml on day 1 to 111 pg/ml on day 7.
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