Key result
Psychotropic medication use is linked to ~218% higher odds of non-shockable rhythm during cardiac arrest.
Why the study?
Psychotropic medication has been associated with a risk for sudden cardiac death, but its association with non-shockable initial rhythms during sudden cardiac arrest was unclear.
Is psychotropic medication use associated with non-shockable initial rhythm in patients experiencing sudden cardiac arrest?
Population
222 subjects with sudden cardiac arrest of cardiac origin and rhythm recording within 30 minutes
Comparison
Psychotropic medication use including antipsychotics, benzodiazepines, and antidepressants versus no psychotropic medication use
Design
Observational cohort study
Authors
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May link psychotropic use to poorer SCA survival via non-shockable rhythms; leaves open causality and confounding.
Observational (n=222)
No
Is psychotropic medication use associated with non-shockable initial rhythm in patients experiencing sudden cardiac arrest?
Odds Ratio: 3.18 (95% CI 1.4–7.23)
p-value: p=0.006
Psychotropic medications, particularly antipsychotics, are associated with non-shockable initial rhythms during sudden cardiac arrest, which may contribute to poorer survival outcomes and explain the risk of sudden cardiac death related to these drugs.
Kauppila et al. (2020) conducted an observational in Sudden cardiac arrest (n=222). Psychotropic medication vs. No psychotropic medication was evaluated on Asystole (ASY) or pulseless electrical activity (PEA) initial rhythm (OR 3.18, 95% CI 1.40-7.23, p=0.006). Psychotropic medication use was significantly associated with presenting in a non-shockable rhythm (asystole or PEA) during sudden cardiac arrest (OR 3.18; 95% CI 1.40-7.23; P=0.006).
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