Key result
New 6MWT equations predict VO2 peak in childhood ALL survivors with ~2.7 mL/kg/min mean bias.
Why the study?
Published prediction equations cannot accurately predict valid maximal oxygen consumption (V̇O2 peak) in childhood acute lymphoblastic leukemia survivors.
Can the 6-Minute Walking Test accurately predict V˙O2 peak in childhood ALL survivors using newly developed clinical and disease-specific equations?
Population
200 childhood ALL survivors with 168 undergoing CPET and 6MWT
Comparison
Predicted V̇O2 peak from new 6MWT-based equations vs measured V̇O2 peak from CPET
Design
Cross-sectional study with random division into derivation and validation groups
Authors
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May offer a practical 6MWT surrogate for VO2 peak in childhood ALL survivors; hypothesis-generating pending prospective validation.
Cross-Sectional (n=168)
Randomly divided into derivation and validation groups
Can the 6-Minute Walking Test accurately predict V˙O2 peak in childhood ALL survivors using newly developed clinical and disease-specific equations?
Mean Difference: 2.67 (95% CI -9.64–14.98)
Newly developed equations based on the 6-Minute Walking Test can predict V˙O2 peak in childhood ALL survivors, providing a practical tool for assessing cardiorespiratory fitness.
Labonté et al. (2020) conducted a cross-sectional in Childhood acute lymphoblastic leukemia (ALL) survivors (n=168). 6-Minute Walking Test (6MWT) prediction equations vs. Measured VO2 peak (cardiopulmonary exercise test) was evaluated on Accuracy between measured and predicted VO2 peak (mean bias) (Mean bias 2.67, 95% CI -9.64 to 14.98). New clinical and disease-specific equations based on the 6-Minute Walking Test predicted VO2 peak in childhood ALL survivors with a mean bias of 2.51 to 2.67 mL/kg/min.
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