Key result
Integrating valvular, arterial, and ventricular variables improves AS severity assessment over standard parameters.
Why the study?
Do newer comprehensive approaches improve the assessment of disease severity and prognosis in patients with aortic stenosis compared to standard parameters?
Do newer comprehensive approaches improve the assessment of disease severity and prognosis in patients with aortic stenosis compared to standard parameters?
A comprehensive evaluation of aortic stenosis severity incorporating valvular, arterial, and ventricular variables may improve prognostic assessment beyond standard parameters.
May support integrated valvular-arterial-ventricular assessment in aortic stenosis; leaves open prospective validation before practice change.
"Degenerative" or calcific aortic stenosis is a complex, multifaceted, systemic disease that is not solely limited to the aortic valve but also includes reduced arterial compliance as well as alterations of left ventricular geometry and function. This particular nature of the disease underscores the need for a more comprehensive evaluation of disease severity going beyond the standard parameters routinely used to assess stenosis severity (i.e., peak jet velocity, pressure gradients, valve effective orifice area) or left ventricle function (i.e., left ventricular ejection fraction). The present paper thus proposes to review newer approaches to improve the quantification of disease severity taking into account the interrelation between the different valvular, arterial, and ventricular variables that may be responsible for the appearance of symptoms and/or poorer prognosis in patients with aortic stenosis.
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Pîbarot et al. (2012) conducted a review in Aortic Stenosis. Newer approaches to quantify disease severity vs. Standard parameters was evaluated. Comprehensive evaluation of aortic stenosis severity requires newer approaches that integrate valvular, arterial, and ventricular variables beyond standard parameters.
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