Key result
Increased basic heart rate is linked to decreased turbulence onset and attenuated slope only in men.
Why the study?
The physiological properties of heart rate turbulence and the influence of basic heart rate and sex on HRT have not been clarified in a large cohort of healthy persons.
Do basic heart rate and sex influence heart rate turbulence in healthy subjects?
Observational (n=95)
Do basic heart rate and sex influence heart rate turbulence in healthy subjects?
p-value: p=<0.0001
Basic heart rate and sex significantly influence heart rate turbulence parameters and should be accounted for when using HRT for noninvasive risk stratification.
Basic heart rate and sex modulate HRT parameters in healthy subjects; leaves open need for adjustments in risk stratification before clinical adoption.
Acceleration and deceleration of the heart rate after the occurrence of a ventricular premature complex is characterized as heart rate turbulence (HRT). Two parameters quantify heart rate turbulence: onset and slope. The physiological properties have not been clarified in a large cohort of persons yet. This study evaluated properties of HRT, and focused on the influence of basic heart rate and sex on HRT. Using a special protocol, 95 persons were studied prospectively. HRT and its physiological properties were determined in 95 persons using Holter ECGs. The authors found 24% with a turbulence onset 0% and 5% with a turbulence slope <2.5 ms/RRI. Mean heart rate during Holter differed significantly between women and men (745 vs 817 ms, P < 0.0001). A linear, weighted regression model revealed that an increased heart rate before a ventricular premature complex is associated with a decreased turbulence onset (P < 0.0001). Turbulence slope was attenuated by basic heart rate only in men (P = 0.0022). On the contrary, the study detected no influence of the basic heart rate on turbulence slope in women (P = 0.0015 for the comparison between women and men). Basic heart rate and sex show an influence on HRT and should be considered when using HRT for noninvasive risk stratification.
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Schwab et al. (2004) conducted an observational in Healthy Subjects (n=95). Basic heart rate and sex was evaluated on Heart rate turbulence onset and slope (p=<0.0001). Increased basic heart rate was associated with decreased heart rate turbulence onset (P<0.0001) and attenuated turbulence slope in men but not women (P=0.0015 for sex comparison).
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