Preclinical study demonstrates that inhibiting ZDHHC11 reverses immune evasion in gastric cancer, highlighting the saSNF2-ZDHHC11 axis as a target to potentiate immunotherapy.
T cell infiltration in vivo. Pharmacological inhibition of ZDHHC11 reverses immune evasion and synergizes with anti-PD-1 checkpoint blockade. These findings establish SA as a multifaceted driver of GC and highlight the saSNF2-ZDHHC11 axis as a target to potentiate immunotherapy.
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Xie et al. (2026) studied this question.
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