Key result
Cloning identifies Aralar2 as a calcium-binding mitochondrial carrier sharing ~78% identity with Aralar1.
Why the study?
A second member of the calcium-binding mitochondrial carrier subfamily expressed in human non-excitable tissues had not been characterized.
Identifies ARALAR2 as a calcium-regulated mitochondrial carrier expressed in non-excitable tissues, identical to citrin, the gene mutated in type-II citrullinaemia.
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May link mitochondrial calcium defects to type II citrullinemia; extends Aralar characterization to non-excitable tissues.
Arco et al. (2000) studied this question. ARALAR2 (citrin) cloning and characterization was evaluated on Gene cloning and protein characterization. Aralar2 (citrin) is a calcium-binding mitochondrial carrier expressed in liver and non-excitable tissues, sharing 78.3% identity with Aralar1.
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