Key result
ACE gene I/D polymorphism shows no association with major depressive disorder risk.
Why the study?
The influence of ACE gene I/D polymorphism on the risk of major depressive disorder was unclear in the Turkish population.
Is the ACE gene I/D polymorphism associated with the risk of major depressive disorder in a Turkish population?
Case-Control (n=556)
Is the ACE gene I/D polymorphism associated with the risk of major depressive disorder in a Turkish population?
The ACE I/D polymorphism does not appear to be associated with major depressive disorder in the Turkish population.
No association seen in Turkish cohort; leaves open ethnic or sample-size effects in future studies.
Background Major depressive disorder (MDD) is a complex disease and a significant health problem that is prevalent across the world. Angiotensin-converting enzyme (ACE) has an important role in renin-angiotensin system (RAS) and converts inactive angiotensin I to a potent vasopressor and aldosterone-stimulating peptide angiotensin II. Levels of ACE in plasma vary according to the insertion/deletion (I/D) polymorphism of ACE gene. Objective The aim of the current study was to examine the influence ACE gene I/D variations on the risk of MDD. Methods In the present case-control study, we analyzed ACE I/D polymorphism in 346 MDD patients and 210 healthy subjects using polymerase chain reaction technique. Results Comparing the two groups, no significant difference was observed with regard to either genotype distributions or allele frequencies of the I/D polymorphism of ACE gene. Discussion Our findings suggest that the ACE I/D polymorphism is not associated with MDD in Turkish case-control study. Further studies are still needed.
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İnanır et al. (2016) conducted a case-control in Major depressive disorder (n=556). ACE gene I/D polymorphism vs. Healthy subjects was evaluated on Risk of major depressive disorder. The ACE gene I/D polymorphism was not significantly associated with the risk of major depressive disorder in a Turkish case-control study.
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