Key result
Localized low-dose tPA shows ~96% right atrial thrombus reduction without major bleeding.
Why the study?
The optimal treatment method for catheter-related right atrial thrombosis remains unknown.
Does catheter-directed low-dose tPA reduce thrombus size in a patient with a right atrial thrombus caused by a central venous catheter?
Case Report (n=1)
Does catheter-directed low-dose tPA reduce thrombus size in a patient with a right atrial thrombus caused by a central venous catheter?
Catheter-directed low-dose tPA successfully reduced right atrial thrombus volume by 96% without major bleeding, suggesting it as a potential alternative to systemic thrombolysis or surgery.
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Catheter-directed low-dose tPA was associated with marked thrombus reduction without major bleeding in this case; leaves open its broader role versus systemic therapy or surgery.
Orgeron et al. (2015) conducted a case report in Right atrial thrombus caused by a central venous catheter (n=1). Localized recombinant tissue plasminogen activator (tPA) was evaluated on Thrombus volume reduction. Localized low-dose tPA administered through a central venous catheter reduced right atrial thrombus volume by 96% (from 30 × 16 × 22 mm to 10 × 8 × 5 mm) without major bleeding complications.
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