Key result
Childbirth in women with Turner karyotype is linked to ~359% higher circulatory disease risk under 40.
Why the study?
Pregnancies in women with Turner karyotype are high-risk with increased maternal mortality and morbidity, but long-term mortality and morbidity after childbirth are unclear.
Does childbirth increase mortality and morbidity in women with Turner karyotype?
Cohort (n=1,732)
Does childbirth increase mortality and morbidity in women with Turner karyotype?
Hazard Ratio: 4.59 (95% CI 2.75–7.66)
Women with Turner karyotype who give birth do not experience increased mortality during pregnancy and follow-up, but they have a significantly higher rate of circulatory diseases and aortic aneurysm, underscoring the need for thorough pre-pregnancy cardiac evaluation.
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Supports post-partum aortic surveillance in Turner syndrome despite no mortality; confirms circulatory risks but leaves practice change open.
Hagman et al. (2013) conducted a cohort in Turner karyotype (n=1,732). Turner karyotype and childbirth vs. Matched women from the Medical Birth Register and women with Turner karyotype without childbirth was evaluated on Diseases of the circulatory system under the age of 40 years (HR 4.59, 95% CI 2.75-7.66). Women with Turner karyotype who gave birth experienced no mortality but had a higher risk of circulatory diseases under age 40 compared to matched controls (HR 4.59; 95% CI 2.75-7.66).
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