Key result
Lithium toxicity manifests as reversible CHB, AF, and sinus bradycardia in a single patient.
Why the study?
Lithium toxicity has a narrow therapeutic index with cardiovascular effects ranging from benign ST-T changes to fatal arrhythmias, requiring detailed characterization of ECG manifestations.
Case Report (n=1)
Lithium toxicity can present with a wide variety of reversible electrocardiographic manifestations including junctional rhythm, complete heart block, and atrial fibrillation.
Answers are grounded in this paper and cite their sources.
Recognizing reversible bradyarrhythmias may aid lithium toxicity management; one case leaves open systematic study of incidence.
Lithium is a commonly used drug in psychiatric practice. It is used in the treatment of depression and bipolar disorder. It has a narrow therapeutic index with documented adverse effects even near therapeutic levels. It has myriad of manifestations at toxic levels. The cardiovascular effects range from relatively benign ST-T wave changes to fatal arrhythmias. We describe a case of lithium toxicity which presented as a junctional rhythm and later showed a variety of manifestations such as complete heart block, atrial fibrillation, sinus bradycardia, and finally reverted to sinus rhythm at par with serum lithium levels.
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A 2017 study conducted a case report in Lithium toxicity (n=1). Lithium toxicity was evaluated on Electrocardiogram manifestations. Lithium toxicity in a single patient manifested as a junctional rhythm, complete heart block, atrial fibrillation, and sinus bradycardia, which reverted to sinus rhythm as serum levels normalized.
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