May 1, 1969American Journal of Epidemiology
Relationships Between Familial Aggregation of Coronary Heart Disease and Risk Factors in the General Population1
Key result
Elevated adult CV risk factors correlate with higher parental CHD mortality, particularly early paternal deaths.
Why the study?
Familial aggregation of coronary heart disease and its relationship with elevated serum cholesterol, systolic blood pressure, or blood glucose levels in adults was not fully understood.
Does the presence of elevated cardiovascular risk factors in adults correlate with parental mortality due to CHD?
Population
Adult participants in an epidemiologic study covering an entire community in Tecumseh, Michigan
Comparison
Participants with elevated serum cholesterol, systolic blood pressure, or blood glucose vs those without elevated levels
Design
Observational epidemiologic study
Authors
Discussion
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Implication
Familial aggregation of cardiovascular risk factors (cholesterol, blood pressure, glucose) is strongly associated with early parental mortality from coronary heart disease.
Study Design
Type
Observational
Multicenter
No
Structured PICO
Does the presence of elevated cardiovascular risk factors in adults correlate with parental mortality due to CHD?
P
Population
Adult participants from a community epidemiologic study in Tecumseh, Michigan, with elevated cardiovascular risk factors compared to age- and sex-matched controls.
E
Exposure
Elevated levels of serum cholesterol, systolic blood pressure or blood glucose after challenge (observational exposure)
C
Comparator
Subjects of the same sex and age without elevated levels of these risk factors
O
Outcome
Parental mortality due to coronary heart disease (CHD)hard clinical
Familial aggregation of cardiovascular risk factors (cholesterol, blood pressure, glucose) is strongly associated with early parental mortality from coronary heart disease.
Cite This Study
Deutscher et al. (1969) conducted an observational in Coronary heart disease. Elevated levels of serum cholesterol, systolic blood pressure, or blood glucose vs. Subjects of the same sex and age without elevated levels of these risk factors was evaluated on Parental mortality due to coronary heart disease (CHD). Elevated cardiovascular risk factors in adults were associated with increased parental mortality due to CHD, particularly when paternal deaths occurred relatively early in life.