Key result
Exercise training increases white adipose tissue endothelial cell density by ~37% in male rats.
Why the study?
The effects of exercise training on endothelial cell density and angiogenic factor expression in white adipose tissue of rats were examined to understand vascular adaptations.
Does a 9-week exercise training program alter the density of endothelial cells in the white adipose tissue of Wistar male rats?
Does a 9-week exercise training program alter the density of endothelial cells in the white adipose tissue of Wistar male rats?
Effect estimate: 1.37-fold increase
Exercise training in rats increases the density of endothelial cells in white adipose tissue and upregulates angiogenic factors, likely due to a reduction in adipocyte size and number.
Should not change clinical practice; hypothesis-generating for exercise effects on adipose angiogenesis in humans.
We examined the effects of a 9-week exercise training (TR) in Wistar male rats, beginning at 4 weeks of age, on the density of endothelial cells (ECs) in epididymal white adipose tissue (WAT) and the mRNA expression of angiogenic factors in adipose tissue stromal vascular fraction (SVF) cells. The number of ECs and mRNA expressions were assessed by lectin staining and real-time reverse transcriptase-polymerase chain reaction, respectively. Compared with control (CR) rats, TR rats gained weight more slowly and had significantly lower final weight of WAT due to the reduction in the size and the number of adipocytes. TR significantly increased the number of ECs per square millimeter and per adipocyte (1.37- and 1.23-fold, respectively) in WAT. This is probably because the number of adipocytes is fewer while the number of ECs is constant in the WAT of TR rats, because the regression line of TR rats for adipocyte number-dependent EC number was shifted toward the left without significant differences in the slopes between groups. TR also induced the upregulation of mRNA expression of vascular endothelial growth factor (Vegf)-A and Vegf-receptor-2 in SVF cells, thereby retaining a constant number of ECs in the WAT.
No takes yet. Share an insight, caveat, or question.
Hatano et al. (2010) studied this question. Exercise training vs. Control rats was evaluated on Density of endothelial cells in epididymal white adipose tissue (1.37-fold increase). A 9-week exercise training significantly increased the number of endothelial cells per square millimeter (1.37-fold) and per adipocyte (1.23-fold) in the white adipose tissue of male rats.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: