February 1, 1985AJP Regulatory Integrative and Comparative Physiology
Effect of stimulation of nucleus raphe dorsalis on carotid blood flow. II. The cat
Key result
Dorsal raphe stimulation lowers carotid vascular resistance in cats via serotonin and the facial nerve.
- n=74
Why the study?
The effects and mechanisms of dorsal raphe nucleus stimulation on carotid blood flow and vascular resistance were not fully understood.
Population
74 cats
Comparison
Electrical and chemical stimulation of dorsal raphe nucleus vs baseline
Design
Experimental study with electromagnetic flow probes measuring carotid flow
Authors
Discussion
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Implication
Hypothesis-generating for serotonergic carotid vasomotor control; leaves open translation to human cerebrovascular regulation.
PICO
P
Population
74 cats undergoing electrical and chemical stimulation of the dorsal raphe nucleus to measure carotid blood flow.
I
Intervention / Comparator
Stimulation of the dorsal raphe nucleus (DRN)
O
Primary Outcome
carotid vascular resistance
Cite This Study
Goadsby et al. (1985) studied this question. Stimulation of the dorsal raphe nucleus (DRN) was evaluated on carotid vascular resistance. Stimulation of the dorsal raphe nucleus in cats caused a frequency-dependent decrease in common carotid vascular resistance, mediated by central serotonin and the facial nerve.