Key result
Cancer weight loss is linked to ~35% lower lipoprotein lipase activity, potentially driving hypertriglyceridemia.
Why the study?
The relationship between plasma lipoprotein lipase activity and malignancy-associated weight loss in cancer patients was not well characterized.
Is plasma lipoprotein lipase activity reduced in cancer patients with weight loss compared to normal volunteers?
Population
28 cancer patients with varying degrees of weight loss and 16 normal volunteers
Comparison
Cancer patients vs normal volunteers
Design
Case-control study
Authors
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May inform mechanisms of dyslipidemia in cachectic cancer patients; leaves open any clinical role for LPL assessment or modulation.
Case-Control (n=44)
Is plasma lipoprotein lipase activity reduced in cancer patients with weight loss compared to normal volunteers?
Effect estimate: 35.4% decrease
p-value: p=<0.001
Cancer patients with weight loss exhibit significantly decreased total lipoprotein lipase activity, which may partially explain the hypertriglyceridemia observed in this population.
Vlassara et al. (1986) conducted a case-control in Malignancy-associated weight loss (n=44). Cancer with weight loss vs. Normal volunteers was evaluated on Total lipoprotein lipase activity (35.4% decrease, p=<0.001). Cancer patients with weight loss exhibited a 35.4% decrease in total lipoprotein lipase activity compared to normal volunteers (P<0.001), potentially contributing to hypertriglyceridemia.
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