Key result
Lung cancer tissue shows ~1.9-fold higher LPL activity despite lower gene expression than noncancer tissue.
Why the study?
The study tested the hypothesis that lipoprotein lipase gene expression and enzyme activity differ between lung cancer tissue and adjacent noncancer lung tissue.
Population
42 patients with resectable non-small cell lung cancer
Comparison
Lung cancer tissue vs adjacent noncancer lung tissue
Design
Cross-sectional study
Authors
Loading...
Does not inform clinical decisions; leaves open LPL's mechanistic role in lung cancer.
Cross-Sectional (n=42)
Effect estimate: 1.9-fold median difference
p-value: p=< .0001
Lung cancer tissue exhibits higher lipoprotein lipase activity despite lower gene expression compared to adjacent healthy tissue, suggesting a mechanism for increased lipid nutrient supply to tumors.
Černe et al. (2007) conducted a cross-sectional in resectable non-small cell lung cancer (n=42). Lung cancer tissue vs. Adjacent noncancer lung tissue was evaluated on LPL activity (1.9-fold median difference, p=< .0001). Lung cancer tissue had 1.9-fold higher median LPL activity (P < .0001) but 3.8-fold lower median LPL gene expression (P < .0001) compared to adjacent noncancer lung tissue.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: