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The unusuai cyclodepsipeptide dolastatin 17 (1) was isolated from the Papua New Guinea sea hare Dolabella auricularfa and found to contain a new acetylenic p-amino acid designated dolayne (Doy).Dolastatin 17 exhibited significant human cancer cell growth inhibitory activity (GI,, 0.L5-0.74pg/mL range).
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Pettit et al. (1998) studied this question.
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