Key result
Intrathecal morphine linked to ~63% less intra-operative blood loss during pediatric scoliosis surgery.
Why the study?
The impact of intrathecal morphine on blood loss and hemodynamic stability during pediatric idiopathic scoliosis surgery was not well established.
Does intrathecal morphine reduce blood loss and improve hemodynamic stability in pediatric patients undergoing idiopathic scoliosis surgery?
Population
256 pediatric patients undergoing idiopathic scoliosis surgery
Comparison
Intrathecal morphine vs no intrathecal morphine
Design
Retrospective cohort study
Follow-up
Intra-operative
Authors
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May support reduced blood loss with intrathecal morphine in pediatric scoliosis surgery; leaves open need for prospective trials before practice change.
Cohort (n=256)
Does intrathecal morphine reduce blood loss and improve hemodynamic stability in pediatric patients undergoing idiopathic scoliosis surgery?
Effect estimate: 63.4% decrease
Absolute Event Rate: 655.8% vs 1793.1%
p-value: p=< 0.0001
Intrathecal morphine significantly decreases intra-operative blood loss and transfusion requirements while enhancing blood pressure stability during pediatric scoliosis surgery.
Lesniak et al. (2013) conducted a cohort in pediatric idiopathic scoliosis (n=256). Intrathecal morphine vs. No intrathecal morphine was evaluated on 20% decrease in blood loss and hemodynamic stability (63.4% decrease, p=< 0.0001). Intrathecal morphine significantly reduced intra-operative blood loss compared to no intrathecal morphine (655.8 vs 1793.1 ml, P<0.0001) during pediatric scoliosis surgery.
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