Key result
Higher R2CHA2DS2-VASc score linked to ~41% greater long-term mortality risk in ACS patients.
Why the study?
The predictive value of CHA2DS2-VASc and R2CHA2DS2-VASc scores for long-term mortality in patients with ACS and their comparison with TIMI and GRACE scores was unclear.
Do CHA2DS2-VASc and R2CHA2DS2-VASc scores predict long-term all-cause mortality in patients with acute coronary syndromes compared to TIMI and GRACE scores?
Cohort (n=2,557)
Yes
Do CHA2DS2-VASc and R2CHA2DS2-VASc scores predict long-term all-cause mortality in patients with acute coronary syndromes compared to TIMI and GRACE scores?
Hazard Ratio: 1.41 (95% CI 1.35–1.47)
p-value: p=<0.0001
The CHA2DS2-VASc and R2CHA2DS2-VASc scores are simple, significant predictors of long-term all-cause mortality in ACS patients, offering a reasonable alternative to more complex ACS-specific scores like GRACE.
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These scores predict long-term mortality in ACS; leaves open routine adoption pending prospective validation versus GRACE/TIMI.
Kiliszek et al. (2015) conducted a cohort in acute coronary syndrome (n=2,557). R2CHA2DS2-VASc score vs. TIMI and GRACE scores was evaluated on all-cause mortality (HR 1.41, 95% CI 1.35-1.47, p=<0.0001). The R2CHA2DS2-VASc score was a significant independent predictor of long-term all-cause mortality in patients with acute coronary syndrome (HR 1.41).
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