Key result
Amphetamine-dextroamphetamine use for ADHD linked to severe nonischemic cardiomyopathy with ~9% LVEF.
Why the study?
Dextroamphetamine-induced cardiomyopathy is an increasingly common cause of heart failure in teenagers and young adults due to rising medication use and improper use for concentration enhancement.
Case Report (n=1)
No
Amphetamine-dextroamphetamine use for ADHD can induce severe cardiomyopathy, highlighting the need for awareness and multidisciplinary management in patients with dual diagnoses.
Prompts cardiac monitoring in young ADHD patients on dextroamphetamine; single case report leaves open population risk estimates.
In teenagers and young adults, dextroamphetamine-induced cardiomyopathy is becoming a more common cause of heart failure. More patients are at risk of this cardiac manifestation due to the medication's increased use in the treatment of attention-deficit/hyperactivity disorder (ADHD), particularly those who are unaware of the risks associated with using it improperly to improve concentration for poor performance. It becomes imperative to draw attention to the link between heart failure and amphetamine-dextroamphetamine usage to raise awareness of this illness. This case study revolves around a 32-year-old man with a complicated medical history who was recently diagnosed with heart failure with reduced ejection fraction (HFrEF < 10%), which was linked to amphetamine-induced cardiomyopathy. His recent diagnosis of ADHD and the treatment that followed raise questions regarding the potential for drug-induced worsening of underlying cardiomyopathy. To address his cardiac and concomitant issues, the patient is currently on a complete pharmaceutical regimen that includes atorvastatin, aspirin, furosemide, spironolactone, enoxaparin, omeprazole, and carvedilol. To maximize results and stop additional cardiac deterioration, patients with dual diagnoses, especially those involving amphetamine use and preexisting cardiac conditions, need to be carefully monitored and managed by a multidisciplinary team.
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Al-Juhani et al. (2024) conducted a case report in Amphetamine-induced cardiomyopathy (n=1). Amphetamine-dextroamphetamine was evaluated on Development of heart failure with reduced ejection fraction. A 32-year-old male developed severe nonischemic cardiomyopathy with an ejection fraction of 8-9% following three months of amphetamine-dextroamphetamine use for ADHD.
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