Key result
PCOS linked to elevated cardiovascular risk markers compared to healthy controls.
Why the study?
Cardiac risk marker levels in obese and non-obese women with PCOS compared to healthy controls were not well characterized.
Do women with polycystic ovary syndrome have elevated levels of cardiac risk markers compared to healthy controls?
Case-Control
Do women with polycystic ovary syndrome have elevated levels of cardiac risk markers compared to healthy controls?
p-value: p=<0.05
Women with PCOS, particularly those who are obese, demonstrate elevated levels of multiple cardiovascular risk biomarkers compared to healthy controls.
Elevated cardiac risk markers in PCOS support heightened vigilance; hypothesis-generating for obesity interactions and needs prospective validation.
OBJECTIVE: To compare cardiac risk markers such as asymmetric dimethyl arginine (ADMA), C-reactive protein (CRP), homocystein (Hcy), plasminogen activator inhibitor-1 (PAI-1), vascular endothelial growth factor (VEGF), angiopoietin-related growth factor 6 (ANGPTL6) in obese and non-obese patients with polycystic ovary syndrome (PCOS). STUDY DESIGN: ) patients diagnosed with PCOS and 30 age-matched healthy controls were included in the study. The ages of subjects were varying between 18 and 30 years. Serum ADMA, CRP, Hcy, PAI-1, VEGF and ANGPTL6 levels were analyzed for each subject. RESULTS: Serum ADMA, CRP, Hcy, PAI-1, VEGF and ANGPTL6 levels were significantly elevated in obese and non-obese women with PCOS in comparison to control subjects (p < 0.05). This elevation was more obvious in the obese PCOS group than in the other group. CONCLUSIONS: Cardiovascular risk markers such as ADMA, CRP, Hcy, PAI-1, VEGF and ANGPTL6 levels are elevated in women with PCOS.
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Elçi et al. (2016) conducted a case-control in Polycystic ovary syndrome. Polycystic ovary syndrome vs. Healthy controls was evaluated on Serum levels of ADMA, CRP, Hcy, PAI-1, VEGF, and ANGPTL6 (p=<0.05). Polycystic ovary syndrome was associated with significantly elevated serum levels of cardiovascular risk markers including ADMA, CRP, Hcy, PAI-1, VEGF, and ANGPTL6 compared to healthy controls (p<0.05).
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