Key result
A single high-intensity defibrillator shock induces LV failure in dogs, reducing cardiac output by ~43%.
Why the study?
A selective, non-ischemic, non-pharmacological left ventricular failure model is needed to evaluate cardiac augmentation techniques in a closed chest animal.
Does a high-intensity defibrillator shock induce selective left ventricular failure in a closed-chest dog model?
Does a high-intensity defibrillator shock induce selective left ventricular failure in a closed-chest dog model?
A high-intensity transventricular defibrillator shock successfully induces a non-ischemic, non-pharmacological left ventricular failure model in closed-chest dogs, useful for evaluating cardiac augmentation techniques.
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High-intensity shocks may model selective LV failure in dogs; leaves open validation for testing cardiac augmentation techniques.
Geddes et al. (1994) studied Left ventricular failure (n=13). High intensity pulse of current from a defibrillator was evaluated on Reduction in cardiac output. A single high-intensity defibrillator shock (175-350 joules) induced selective left ventricular failure in dogs, resulting in an average 42.5% reduction in cardiac output at 4 hours.
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