Key result
The A90L mutation in Staphylococcus aureus nuclease alters T cell recognition and shifts immunodominance.
Why the study?
The mechanism of immunodominance and how single amino acid substitutions affect intramolecular selection of T cell determinants was unclear.
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Identifies critical residues in T cell recognition of bacterial antigens; leaves open applicability to vaccines or human immunity.
Liu et al. (1993) studied this question. Single amino acid substitution (A90L) in Staphylococcus aureus nuclease vs. Wild-type Staphylococcus aureus nuclease was evaluated on T cell recognition and immunodominance shift. A single amino acid substitution (A90L) in Staphylococcus aureus nuclease altered T cell recognition, shifting immunodominance to a previously subdominant determinant (region 112-130).
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