What does this research mean for the field?

Submaximal exercise testing using blood lactate concentration or femoral venous oxygen tension endpoints reliably identifies decreased flow reserve in dogs with class IV heart failure. Novelty: ClaimNovelty.METHODOLOGICAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

January 1, 1996Journal of Veterinary Internal MedicineOpen Access

Submaximal Exercise Testing Using Lactate Threshold and Venous Oxygen Tension as Endpoints in Normal Dogs and in Dogs With Heart Failure

Q: What is the clinical evidence from this study?

Study design: Other. Population: Heart failure (n=19). Intervention: Submaximal graded treadmill exercise testing vs. Normal dogs. Primary outcome: Blood lactate concentration and femoral vein oxygen tension.

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Key result

Submaximal exercise testing using lactate or oxygen endpoints identifies decreased flow reserve in canine heart failure.

n=19

Why the study?

A standardized submaximal exercise test protocol to evaluate exercise capability and flow reserve in dogs of varying sizes and with heart failure was needed.

Does submaximal exercise testing using lactate threshold and venous oxygen tension accurately evaluate exercise capability in normal dogs and dogs with heart failure?

Comparison

Normal dogs vs dogs with class IV heart failure

Design

Chronic instrumentation with graded treadmill exercise testing measuring hemodynamics and blood gases

Authors

MKMark D. KittlesonVeterinary Medical Teaching Hospital LJLynne E. JohnsonSchlumberger (Canada)PPPaul D. PionVeterinary Medical Teaching Hospital

Discussion

Member takes

Implication

Submaximal treadmill testing with lactate or femoral vein PO2 endpoints is feasible across dog sizes; leaves open its role for grading heart failure severity in clinical or translational settings.

Structured PICO

Does submaximal exercise testing using lactate threshold and venous oxygen tension accurately evaluate exercise capability in normal dogs and dogs with heart failure?

Population

19 dogs (12 normal and 7 with experimentally induced class IV heart failure) weighing 15 to 40 kg evaluated using a graded treadmill exercise protocol.

Intervention

Submaximal graded treadmill exercise testing (16% grade at 1, 2, and 3 mph, and 22% and 26% grade at 3 mph) with measurement of blood lactate and venous oxygen tension.

Comparator

Normal dogs vs. dogs with heart failure.

Outcome

Blood lactate concentration and femoral vein PO2.surrogate

Submaximal exercise testing using femoral vein oxygen tension or blood lactate concentration can effectively evaluate exercise capability and identify decreased flow reserve in dogs with heart failure.

Limitations

Unwillingness of some dogs to walk on the treadmill during the preselection phase

Cite This Study

Kittleson et al. (1996) studied Heart failure (n=19). Submaximal graded treadmill exercise testing vs. Normal dogs was evaluated on Blood lactate concentration and femoral vein oxygen tension. Submaximal exercise testing using blood lactate or femoral vein oxygen tension endpoints successfully identified decreased flow reserve in dogs with class IV heart failure.

synapsesocial.com/papers/6ab1ed1c99dd461dc2c8ef14 https://doi.org/10.1111/j.1939-1676.1996.tb02019.x

Topics

Heart failure HFrEF treatment

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Implication

Submaximal treadmill testing with lactate or femoral vein PO2 endpoints is feasible across dog sizes; leaves open its role for grading heart failure severity in clinical or translational settings.

Submaximal Exercise Testing Using Lactate Threshold and Venous Oxygen Tension as Endpoints in Normal Dogs and in Dogs With Heart Failure

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Topics

Submaximal Exercise Testing Using Lactate Threshold and Venous Oxygen Tension as Endpoints in Normal Dogs and in Dogs With Heart Failure

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Topics

Also Consider