Population
Placental tissue from patients with preeclampsia and normal placental tissue, and two trophoblast cell lines
Comparison
In vitro upregulation of miR-95-3p and… vs Control cells / normal placental tissue
Design
Preclinical
Key result
miR-95-3p was expressed at low levels in preeclampsia placental tissue, and its in vitro upregulation promoted trophoblast migration and invasion by targeting EPM2A.
Authors
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Preclinical trophoblast data support exploring miR-95-3p modulation in preeclampsia; human studies required before therapeutic consideration.
miR-95-3p promotes the migration and invasion of trophoblast cells by targeting EPM2A, suggesting a potential mechanism and therapeutic target for preeclampsia.
Gao et al. (2023) studied Preeclampsia. miR-95-3p vs. Normal placental tissue / EPM2A upregulation was evaluated on Trophoblast migration, invasion, and proliferation. miR-95-3p was expressed at low levels in preeclampsia placental tissue, and its in vitro upregulation promoted trophoblast migration and invasion by targeting EPM2A.
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