Key result
Thyme oil and thymol attenuate doxorubicin-induced cardiotoxicity and nephrotoxicity by repressing oxidative stress.
Why the study?
The preventive effects of thyme oil and thymol on doxorubicin-induced renotoxicity, cardiotoxicity, and oxidative stress were not established.
Does thyme oil and thymol prevent doxorubicin-induced nephrotoxicity and cardiotoxicity in Wistar rats?
Population
Wistar rats
Comparison
Thyme oil and thymol versus doxorubicin-induced toxicity
Design
Preclinical experimental study
Authors
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No immediate clinical implications; leaves open translation of rat reno- and cardioprotection to human doxorubicin toxicity.
Does thyme oil and thymol prevent doxorubicin-induced nephrotoxicity and cardiotoxicity in Wistar rats?
Thyme oil and thymol are being investigated for their potential to prevent doxorubicin-induced nephrotoxicity and cardiotoxicity in a preclinical rat model.
Ahmed et al. (2020) studied this question. Thyme oil and thymol abrogated doxorubicin-induced nephrotoxicity and cardiotoxicity in Wistar rats by repressing oxidative stress and enhancing antioxidant defenses.
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