Key result
Brachial low-flow-mediated constriction linked to ~5-fold higher odds of absent post-ischemic vasodilation.
Why the study?
The meaning and clinical significance of brachial artery low-flow-mediated constriction (L-FMC) during ischemia remain unclear.
Is brachial low-flow-mediated constriction associated with delayed or absent flow-mediated dilation in outpatients?
Cross-Sectional (n=179)
No
Is brachial low-flow-mediated constriction associated with delayed or absent flow-mediated dilation in outpatients?
Odds Ratio: 4.8 (95% CI 1.9–12.16)
p-value: p=0.02
Brachial low-flow-mediated constriction is present in nearly 40% of outpatients and is significantly associated with delayed or absent flow-mediated vasodilation, suggesting it may serve as a marker of endothelial dysfunction.
No takes yet. Share an insight, caveat, or question.
May serve as endothelial dysfunction marker in outpatients; hypothesis-generating and requires prospective validation before clinical use.
Irace et al. (2015) conducted a cross-sectional in Endothelial Dysfunction (n=179). Brachial artery low-flow-mediated constriction (L-FMC ≥1%) vs. No constriction (L-FMC <1% or dilation) was evaluated on No vasodilation after ischemia (OR 4.8, 95% CI 1.90-12.16, p=0.02). Brachial artery low-flow-mediated constriction during ischemia was significantly associated with an increased likelihood of having no vasodilation (OR 4.8) or delayed vasodilation (OR 2.6) compared to subjects without constriction.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: