Background: Vitamin D is one of the considerable environmental factors exhibiting immunomodulatory and anti-inflammatory effects.Objective: To conduct a systematic review and meta-analysis to estimate the effect of vitamin D supplements on IL-10 and INFγ levels in patients with multiple sclerosis.Methods: We searched PubMed, Scopus, EMBASE, CINAHL, Web of Science, Ovid, The Cochrane Library and gray literature, including references of selected studies, conference abstracts which were published up to May 2019.We included single-or double-blinded RCTs or open-label trials in which one of the main outcomes was INFγ and/ or IL-10 levels after vitamin D supplementation.Only articles that had been published in English were included.
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Azimi et al. (2019) studied this question.
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