Key result
Aging is linked to progressive declines in cardiac output and microcirculation alongside higher vascular resistance.
Why the study?
Early diagnosis of pathological changes leading to cardiovascular disease requires understanding age-related changes in cardiovascular hemodynamic and microcirculatory parameters in healthy individuals.
Cross-Sectional (n=136)
No
Healthy aging is associated with progressive changes in central and peripheral hemodynamics, including decreased cardiac output and microcirculation, which should be considered normal physiological changes rather than pathology.
Supports viewing these shifts as physiological in healthy aging; leaves open longitudinal outcome links and intervention effects.
BACKGROUND: One of the current issues of fundamental and clinical medicine is the early diagnosis of pathological changes that may lead to the development of cardiovascular disease. AIM: The study aimed to investigate age-related changes in the cardiovascular system in healthy individuals by a comprehensive assessment of the correlations between hemodynamic and microcirculatory parameters at different age. METHODS: The study was conducted on 136 adult volunteers with no clinical or laboratory manifestations of cardiovascular disease. The material was divided into five age groups: adolescence, I and II periods of adulthood, old age, and senile age. Males and females accounted for 50.73% and 49.27%, respectively. Central and peripheral hemodynamic parameters were measured using high-resolution compression oscillometry, ultrasound duplex scanning of aortic arch branches, echocardiography, and reactive hyperemia test on the brachial artery. Microcirculation indices in the skin of the right index finger were studied using a laser Doppler flowmeter before and after the treadmill test. The digital data were processed by the methods of variation statistics using the JASP 0.16.4.0 statistical software package. RESULTS: An age-related decrease in skin microcirculation indices was observed. A significant statistical dependence of changes in microcirculation indices after physical activity in the groups of old and senile age was found. Left ventricular ejection fraction, cardiac output, cardiac index, stroke volume, and stroke index progressively decreased with increasing age; diastolic blood pressure increased; pliability of the brachial artery vascular wall decreased; total and specific peripheral resistance increased. Blood flow indices in the common carotid arteries (diameter and linear and volumetric blood flow velocity) decreased, whereas resistance index and intima-media thickness increased. Blood flow indices in vertebral arteries (linear and volumetric blood flow velocity) and indices of total blood flow to the brain progressively decreased with age. In addition, the dependence of some indices on gender was revealed. CONCLUSIONS: With increasing age in healthy people, changes in central and peripheral hemodynamic parameters occur, which do not lead to cardiovascular diseases. Age-related changes in macro- and microcirculation are best detected during functional stress tests and should be considered in clinical practice as a manifestation of the normal aging process.
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Андреева et al. (2023) conducted a cross-sectional in Healthy (n=136). Increasing age vs. Younger age groups was evaluated on Age-related changes in central and peripheral hemodynamic parameters and microcirculation. Increasing age in healthy individuals is associated with progressive decreases in cardiac output and skin microcirculation, alongside increases in diastolic blood pressure and peripheral resistance.
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