Key result
Gene-based antibody strategies, specifically intrabodies, are emerging as valuable therapeutic tools for prion diseases by targeting precise epitopes of target proteins in vitro and in vivo.
Population
Prion diseases or transmissible spongiform encephalopathies (TSE)
Design
Review
Authors
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Intrabodies may extend targeted options for prion diseases; hypothesis-generating from preclinical data and should not yet change practice.
Intrabodies represent a potential therapeutic strategy for prion diseases by targeting specific epitopes of pathological proteins.
Cardinale et al. (2013) conducted a review in Prion diseases or transmissible spongiform encephalopathies (TSE). Gene-based antibody strategies (intrabodies) was evaluated. Gene-based antibody strategies, specifically intrabodies, are emerging as valuable therapeutic tools for prion diseases by targeting precise epitopes of target proteins in vitro and in vivo.
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