Key result
PVT/VF inducibility in DCM predicts ~52% fast VT recurrence, exceeding both SMVT induction and non-inducibility.
Why the study?
The association of inducibility of PVT/VF or SMVT at programmed ventricular stimulation with long-term sudden death and fast VT risk in idiopathic DCM patients with ICD for secondary prophylaxis was unclear.
Does the inducibility of PVT/VF or SMVT at programmed ventricular stimulation predict sudden death or fast VT recurrences in patients with idiopathic DCM and ICD for secondary prophylaxis?
Population
160 consecutive idiopathic non-ischaemic DCM patients with spontaneous sustained VT/VF or cardiac arrest undergoing ICD implantation
Comparison
Inducibility of PVT/VF or SMVT vs non-inducible patients at programmed ventricular stimulation
Design
Cohort study
Follow-up
Mean 53 +/- 15 months
Authors
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In patients with idiopathic DCM receiving an ICD for secondary prevention, inducibility of PVT/VF during programmed ventricular stimulation is a strong predictor of fast VT recurrences and sudden cardiac death.
Cohort (n=160)
Does the inducibility of PVT/VF or SMVT at programmed ventricular stimulation predict sudden death or fast VT recurrences in patients with idiopathic DCM and ICD for secondary prophylaxis?
Absolute Event Rate: 52% vs 28%
p-value: p=<0.01
In patients with idiopathic DCM receiving an ICD for secondary prevention, inducibility of PVT/VF during programmed ventricular stimulation is a strong predictor of fast VT recurrences and sudden cardiac death.
Rolf et al. (2008) conducted a cohort in Idiopathic non-ischaemic dilated cardiomyopathy (DCM) with spontaneous sustained VT/VF or cardiac arrest (n=160). Inducibility of polymorphic ventricular tachycardia or ventricular fibrillation (PVT/VF) vs. Sustained monomorphic ventricular tachycardia (SMVT) inducibility or non-inducibility was evaluated on Recurrences of fast VT treated by the ICD (p=<0.01). Inducibility of PVT/VF in DCM patients with an ICD predicted a higher rate of fast VT recurrences (52%) compared to SMVT induction (20%) or non-inducibility (28%) (P<0.01).
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