Key result
Low total TFPI levels show no significant association with increased VTE risk.
Why the study?
Limited evidence suggests that low total tissue factor pathway inhibitor (TFPI) levels are associated with increased risk of venous thromboembolism (VTE).
Are low levels of total tissue factor pathway inhibitor (TFPI) associated with an increased risk of venous thromboembolism?
Population
534 VTE cases and 1,091 matched controls from the Longitudinal Investigation of Thromboembolism Etiology
Comparison
Low total TFPI levels (bottom 5%) vs higher TFPI levels (upper 95%)
Design
Nested case-control study
Authors
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Does not support low TFPI as independent VTE risk factor after adjustment; leaves open unadjusted or subgroup associations for prospective study.
Case-Control (n=1,625)
Are low levels of total tissue factor pathway inhibitor (TFPI) associated with an increased risk of venous thromboembolism?
Odds Ratio: 1.7 (95% CI 0.98–2.93)
Low TFPI levels may be associated with increased VTE risk, but the association is attenuated and not statistically significant after full adjustment for other coagulation factors and BMI.
Lutsey et al. (2010) conducted a case-control in Venous thromboembolism (n=1,625). Low total tissue factor pathway inhibitor (TFPI) levels vs. Upper 95% of TFPI levels was evaluated on Venous thromboembolism (OR 1.70, 95% CI 0.98-2.93). Low levels of total tissue factor pathway inhibitor (bottom 5%) were not significantly associated with an increased risk of venous thromboembolism after full adjustment (OR 1.70; 95% CI 0.98-2.93).