January 1, 2001Thrombosis and Haemostasis
Plasma Levels of Free and Total TFPI, Relationship with Cardiovascular Risk Factors and Endothelial Cell Markers
Population
626 patients (277 men and 349 women) attending a metabolic ward for primary prevention of coronary disease
Design
Cross-sectional
Authors
Discussion
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Member takes
Implication
Separate f-TFPI and t-TFPI assessment is warranted in future cohorts; leaves open their independent prognostic value beyond conventional risk factors.
Structured PICO
P
Population
626 patients (277 men and 349 women) attending a metabolic ward for primary prevention of coronary disease
O
Outcome
Influence of cardiovascular risk factors on plasma levels of f-TFPI and relations with other endothelial derived moleculessurrogate
Free and total TFPI are regulated differently, with f-TFPI strongly correlating with endothelial cell markers and t-TFPI more related to conventional cardiovascular risk factors like LDL-C.
Cite This Study
Morange et al. (2001) studied this question.