Key result
Retrograde venous ethanol adrenal ablation in monkeys proves dangerous and ineffective, causing severe hypertension and tachycardia.
Why the study?
The safety and effectiveness of venous ethanol injection for adrenal gland ablation were uncertain.
Key points are not available for this paper at this time.
Population
Nine monkeys undergoing left adrenal gland ablation
Comparison
Venous ethanol injection with or without alpha- or beta-adrenergic blocker pretreatment
Design
Experimental animal study
Adrenal ethanol ablation risks hypertensive crisis without complete tissue destruction; leaves open whether modified techniques merit further study.
Venous injection of ethanol was used to ablate the left adrenal gland in nine monkeys. Severe hypertension and tachycardia occurred in all animals not pretreated with alpha- or beta-adrenergic blockers. On postmortem examination the left adrenal glands were reduced in size but still retained some normal tissue. This procedure, while technically simple, is neither effective nor safe.
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Doppman et al. (1984) studied this question. Retrograde venous ethanol injection for adrenal ablation in monkeys caused severe hypertension and tachycardia and failed to completely destroy normal tissue, proving ineffective and dangerous.
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