Key result
Autonomic blockade with atropine and metoprolol attenuated the systolic arterial pressure response to static and dynamic handgrip exercise by 9-12 mmHg (P<0.05).
Why the study?
Does combined parasympathetic and beta-adrenergic blockade with atropine and metoprolol alter the haemodynamic responses to static and dynamic handgrip exercise in healthy men?
Population
6 healthy men
Comparison
Combined parasympathetic and beta-adrenergic… vs Control conditions during static and dynamic…
Design
Other
Follow-up
approximately 6 min (acute exercise duration)
Authors
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Autonomic blockade modestly attenuates handgrip pressor responses in healthy men; leaves open non-autonomic mechanisms in exercise hypertension.
Does combined parasympathetic and beta-adrenergic blockade with atropine and metoprolol alter the haemodynamic responses to static and dynamic handgrip exercise in healthy men?
Effect estimate: 9-12 mmHg lower
p-value: p=<0.05
Static and dynamic exercise of small muscle groups produce equally large pressor responses that are only slightly attenuated by autonomic blockade.
Lewis et al. (1983) studied Healthy (n=6). Autonomic blockade with atropine and metoprolol vs. Control conditions (without drugs) was evaluated on Systolic arterial pressure response to handgrip exercise (9-12 mmHg lower, p=<0.05). Autonomic blockade with atropine and metoprolol attenuated the systolic arterial pressure response to static and dynamic handgrip exercise by 9-12 mmHg (P<0.05).
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