Key result
Platelet-derived growth factor (PDGF) induces the generation of a vascularized connective tissue stroma and modulates angiogenesis by attracting inflammatory cells and acting directly on endothelial cells.
Design
Review
Authors
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PDGF's angiogenic effects in ischemia warrant no practice change; leaves open receptor-targeted trials in myocardial infarction.
This review highlights the critical role of PDGF and its receptors in angiogenesis during physiological and pathological processes, including ischemia and myocardial infarction.
Battegay et al. (1996) conducted a review in Angiogenesis. Platelet-derived growth factor (PDGF) was evaluated. Platelet-derived growth factor (PDGF) induces the generation of a vascularized connective tissue stroma and modulates angiogenesis by attracting inflammatory cells and acting directly on endothelial cells.
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