Key result
Endoscopic transnasal treatment was successfully used in two patients with sinonasal Ewing sarcoma, with one patient remaining disease-free after 5 years of follow-up.
Case Report (n=2)
Endoscopic transnasal resection is a feasible approach for managing selected patients with sinonasal Ewing sarcoma, potentially reducing morbidity compared to external approaches.
Hypothesis-generating for endoscopic resection in sinonasal Ewing sarcoma; prospective studies needed before practice change.
The extra-skeletal form is an unusual type of Ewing sarcoma (ES) arising from soft tissue and in the literature there are reports of less than 50 patients describing the tumor in the paranasal sinuses and skull base. The histological diagnosis is crucial to plan the correct treatment and the molecular confirmation is mandatory in equivocal patients. A multimodality treatment with chemotherapy, surgery and radiotherapy improved the outcomes of these diseases during the last decades and a free-margin resection with the endoscopic transnasal technique is one of the most recent ways to manage these pathologies in selected patients, reducing the morbidities of the external approaches and preserving the quality of life of the patient.Here, the authors present the first patient of primary sinonasal ES free from disease after 5 years of follow-up and treated with an endoscopic endonasal approach and a second patient of sinonasal metastases of ES treated with and endoscopic transnasal approach.
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Lepera et al. (2016) conducted a case report in Ewing sarcoma of the sinonasal tract (n=2). Endoscopic transnasal approach was evaluated. Endoscopic transnasal treatment was successfully used in two patients with sinonasal Ewing sarcoma, with one patient remaining disease-free after 5 years of follow-up.
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