Key result
Essential hypertension is linked to ~32% higher sVCAM-1 levels compared to normotensive controls.
Why the study?
Blood pressure may modify serum concentrations of soluble cell adhesion molecules in essential hypertension patients, but differences between compensated and non-compensated patients were unclear.
Are serum levels of sE-selectin and sVCAM-1 higher in patients with essential hypertension compared to normotensive subjects?
Population
Patients with essential hypertension (compensated and non-compensated) and normotensive volunteers
Comparison
Essential hypertension patients vs normotensive subjects
Design
Observational cross-sectional study
Authors
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Elevated CAMs may mark endothelial activation in EH; case-control data leave open biomarker utility pending prospective validation.
Observational
Are serum levels of sE-selectin and sVCAM-1 higher in patients with essential hypertension compared to normotensive subjects?
Absolute Event Rate: 796% vs 605%
p-value: p=<0.0001
Essential hypertension is associated with elevated levels of soluble cell adhesion molecules (sE-selectin and sVCAM-1), suggesting endothelial activation, particularly in non-compensated patients.
Palomo et al. (2003) conducted an observational in Essential hypertension. Essential hypertension vs. Normotensive subjects was evaluated on Serum levels of sVCAM-1 (ng/mL) (p=<0.0001). Essential hypertension was associated with significantly higher serum levels of sVCAM-1 (796 vs 605 ng/mL, p<0.0001) and sE-selectin (71 vs 48 ng/mL, p<0.0001) compared to normotensive subjects.
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